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KMID : 0391419920020010072
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Korean Journal of Lipidology
1992 Volume.2 No. 1 p.72 ~ p.80
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Prevalence of Hyperlipidemia and other Risk Factors of Coronary Artery Disease in Korean Children
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Abstract
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Based on large-scale epidemiological, and experimental evidence, there is increasing consensus that lipid levels in children to a large extent determine the rate of coronary artery disease (CAD) in adult population. Therefore evaluation,
treatment,
and
follow-up of children at high risk of future cardiovascular disease constitutes the core of what has come to be known as the practice of pediatric preventive cardiology.
In this study, the prevalence of risk factors of coronary artery disease (total cholesterol>200 mg/dL, LDL cholesterol?130 mg/dL, systemic hypertension, hyperglycemia, obesity, family history for CAD and physical activity)were estimated in
children. The
study subjects were 913 boys and 887 girls aged 6 to 15 years. Total cholesterol and triglyceride levels are significantly higher in girls than in boys(p=0.001 and p=0.0018, respectively). HDL cholesterol levels are higher in boys than in girls,
but it
is not statistically significant. When compared the lipid levels between age groups, there is significant difference in female triglyceride levels (P=0.0095) and are significant differences in male total cholesterol(p=0.0087) and HDL cholesterol
levels
(p=0.001). The prevalence of total cholesterol>200 mg/dL was 8.0; that of hyperglycemia, 0.3%; that of systemic hypertension, 0.9%; that of hyperglycemia. 0.3%; that of obesity, 4.7%; that of family history for CAD. 3.8%; that of low physical
activity,
35.4%, respectively.
Wynder's universal cholesterol screening protocol were adapted into the present study. The subjects were categorized into morderate risk group in 17.6%, high risk group in 5.2% and very high risk group in 1.9%. About 25% of population were
subject
to
have fasting lipoprotein analysis of their blood.
In conclusion, it is desirable to screen the cholesterol level universally in Korean children at the age of 2 as it would be possible. And it should be emphasized that the children of risk group and/or having family history of CAD should be
checked
their risk factors including cholesterol and lipoproteins. The results of this study also would be useful as one of the basic data base for early prevention and management of coronary heart disease in pediatric population of Korea.
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KEYWORD
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